All Safe Locations and Combinations in Resident Evil Requiem: Completing & Solving

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Throughout the Resident Evil series, safes are a common feature, always holding valuable rewards. In Resident Evil Requiem, you’ll find four metal safes hidden across Rhodes Hill Critical Care Center and Raccoon City. To open them, you’ll need to discover the correct combination from specific documents or use this guide as a shortcut. Here’s how to unlock all the safes in the game.

Safe 1: Rhodes Critical Care Center Bar & Lounge
The bar and lounge area is guarded by three zombies, including one that can sing, which stuns Grace and causes extra damage. Clear the enemies or sneak past them before attempting to open this safe. The pistol Grace brought from the Wrenwood Hotel is on the bar—make sure to grab it if you haven’t already. Use the combination: 10 left, 80 right, 30 left. Inside, grab Antique Coins.

Safe 2: Rhodes Hill Critical Care Examination Room
This safe is behind a dead body on an operating table that won’t attack until she’s rearranged its organs. Once that’s done, access the safe with the code: 30 right, 10 left, 50 right. Inside, you’ll find more Antique Coins, which can be used in the gambling lounge.

Safe 3: Rhodes Hill Critical Care Center Basement
This is the most hidden safe, easily missed in the underground tunnels. It’s located in a small room to the left of the workshop where you’ll likely hide from The Girl. The combination is: 60 right, 40 left, 80 right. Inside, you’ll find the Raccoon Roundup Map for Rhodes Hill, which updates your map with raccoon statue locations, plus 10 handgun bullets.

Safe 4: The Ark Monitor Control Room
This safe is in an unassuming room before entering the main chamber of The Ark. It’s a good hideout from foes while you prepare. Enter the code: 50 left, 60 right, 80 left. Inside, find a med injector, an empty crafting bottle, and a bottle of acid to throw at lickers.

Safe 5: The Ark Sterilisation Chamber
Hidden behind broken glass in a small room near a sheet, this is one of the trickier safes to spot due to the area’s danger. The combination is: 10 right, 90 left, 20 right. Inside, you’ll find useful items such as a med injector, a Molotov cocktail, and plenty of handgun ammo—essential in this heavily infected zone.