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Home » Unlocking the Briefcase in Resident Evil Requiem: A Step-by-Step Guide

Unlocking the Briefcase in Resident Evil Requiem: A Step-by-Step Guide

Emily Smith by Emily Smith
March 1, 2026
in Gaming
Reading Time: 2 mins read
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Unlocking the Briefcase in Resident Evil Requiem: A Step-by-Step Guide
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While exploring Resident Evil Requiem, you’ll come across many locked doors and boxes. One of the more challenging items to figure out is the briefcase in the S.T.A.R.S. Office on the upper floor of the R.P.D., especially during the second half of the game. However, unlocking it is worth the effort because it contains a very helpful charm that will improve Leon’s combat abilities moving forward. If you’re ready to find the combination, here’s how to do it.

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There’s a specific way to uncover the combination inside R.P.D., and we’ll walk you through the steps. If you just want the answer and don’t want to go through the process, you can skip ahead and read the combination. Let’s get started.

How to Find the Briefcase Combination in Resident Evil Requiem

Barry’s To-Do List and Captain Wesker’s Hidden Library Card

First, leave the locker room with the briefcase behind you. Check the nearby desk in the main S.T.A.R.S. Office. On it, you’ll find Barry’s To-Do List. It mentions a missing library book that Captain Wesker borrowed last.

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Next, go into Captain Wesker’s office, which is directly to the left of the locker room. Open his desk drawer; it will be empty at first. Interact with it again, and a library card will fall out. This card references a book titled The Medicinal Benefits of Herbs. Looks like you need to visit the library!

Visiting the Library and Finding the Book

Head to the library down the hall. You need to locate the book The Medicinal Benefits of Herbs. It is on the second floor of the library.

Image of the Library and Book

When you open this book, you’ll see a photo inside. Interact with it and note the phrase: “Rising Rookie Rebecca.” With this key piece of information, it’s time to go back and open the briefcase.

How to Open the Briefcase

The briefcase has a 3-digit combination lock. You need to set each tile by moving it up or down, then confirm the combination. The correct code is “R-R-R”, which stands for the first letters of “Rising Rookie Rebecca” found in the book.

Once entered correctly, the briefcase will open, revealing a special charm called the Power Shades. This charm will upgrade Leon’s firearm to pierce through enemies’ defenses and boost its power for the final shot in the cylinder. This enhancement makes the weapon much more effective against bosses in the final parts of the game, so solving this puzzle is definitely worth the effort.

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Good luck with unlocking the briefcase and maximizing Leon’s firepower!

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Emily Smith

Emily Smith

Emily is a digital marketer in Austin, Texas. She enjoys gaming, playing guitar, and dreams of traveling to Japan with her golden retriever, Max.

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