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It’s clear that Sirens are among the most popular classes to play in Borderlands, and Borderlands 4 is no different. Vex is the game’s main Siren character, and many fans will likely make her their favorite.
With Borderlands 4 coming out this week, players will try out different characters, skills, guns, shields, and loot to find what works best for them. Below is my favorite build for Vex, which I think is the top choice if you focus on proper optimization.
Best Skills for Vex in Borderlands 4
Focus on Status Effects and Elemental Damage
In my experience, boosting elemental and status effect damage is the most effective way to build Vex. You can do this with any of her three Action Skills, and I recommend adjusting your build as you get better weapons. The key is to tailor your skills to match the best gear you find.
Consider exploring other skill trees for additional status effect boosts, like the Bloodletter skill in Incarnate’s tree.
I found that Vex’s Dead Ringer Action Skill and its skill tree work really well for causing status effects. To make the most of this, focus on collecting strong corrosive weapons and gear that boost this damage type.
In the Dead Ringer tree, prioritize skills that improve status effects, such as Portents of Suffering and Prismatic Ichor early on. Mid and late-game skills like Blight Attunement and Necrosis are great for increasing corrosive damage.
Pick Wither as your Augment skill, and aim to get Grim Reaper as your capstone—these will further boost your status effects. For specializations at the end, go for the Killer branch, which includes Killer, Contamination, Afflicting, and Overkill skills to deal extra damage.
Best Weapons and Gear for Vex in Borderlands 4
Ripper or Maliwan Gear is Best for Elemental Damage
When choosing guns and gear, make sure everything works well together. For a corrosive Vex build, I recommend using Ripper or Maliwan guns because both are excellent for elemental and status effect damage.
A Ripper or Maliwan enhancement helps complement whatever weapon you pick. In my playthrough, I mainly relied on Ripper submachine guns, but I also used Ripper shotguns, pistols, and snipers for variety.
Corrosive damage is very effective at draining enemy health. However, having a backup weapon with a different effect can be useful against enemies that are immune to corrosive effects.
For your class mods, look for ones that boost your chosen skills, especially Portents of Suffering, Blight Attunement, and Necrosis. Your shield and relic should support your play style, but a relic with elemental affinity or status effect bonuses is a good choice. Also, consider using a heavy weapon that deals corrosive damage if you can find one.
Overall, Vex is flexible and can be tailored to many play styles. During my solo run, I found her Phase Clone Minions very helpful—they can act as turrets or distract enemies, giving me breathing room as I made my way through the game.
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